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KMID : 0848120180430020053
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International Journal of Oral Biology
2018 Volume.43 No. 2 p.53 ~ p.59
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Single Molecule Method for Molecular Biology
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Kim Jeong-Hee
Jeong Cherl-Hyun
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Abstract
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In order to understand biological phenomena accurately, single molecule techniques using a physical research approach to molecular interactions have been developed, and are now widely being used to study complex biological processes. In this review, we discuss some of the single molecule methods which are composed of two major parts: single molecule spectroscopy and manipulation. In particular, we explain how these techniques work and introduce the current research which uses them. Finally, we present the oral biology research using the single molecule methods.
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KEYWORD
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single molecule FRET, single molecule tracking, super-resolution microscopy, optical tweezer, AFM
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